Maqola

Natural selection interacts with recombination to shape the evolution of hybrid genomes

Molly SchumerCentro de Investigaciones Científicas de las Huastecas “Aguazarca,” Calnali, Hidalgo, MexicoChenling XuCenter for Computational Biology, University of California at Berkeley, Berkeley, CA, USADaniel L. PowellCentro de Investigaciones Científicas de las Huastecas “Aguazarca,” Calnali, Hidalgo, MexicoArun DurvasulaDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USALaurits SkovBioinformatics Research Centre, Aarhus University, Aarhus, DenmarkChris HollandCentro de Investigaciones Científicas de las Huastecas “Aguazarca,” Calnali, Hidalgo, MexicoJohn C. BlazierDepartment of Biology, Texas A&M University, College Station, TX, USASriram SankararamanDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USAPeter AndolfattoDepartment of Ecology and Evolutionary Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USAGil G. RosenthalCentro de Investigaciones Científicas de las Huastecas “Aguazarca,” Calnali, Hidalgo, MexicoMolly PrzeworskiDepartment of Biological Sciences, Columbia University, New York, NY, USA

2018en

ABI

Annotatsiya

To investigate the consequences of hybridization between species, we studied three replicate hybrid populations that formed naturally between two swordtail fish species, estimating their fine-scale genetic map and inferring ancestry along the genomes of 690 individuals. In all three populations, ancestry from the "minor" parental species is more common in regions of high recombination and where there is linkage to fewer putative targets of selection. The same patterns are apparent in a reanalysis of human and archaic admixture. These results support models in which ancestry from the minor parental species is more likely to persist when rapidly uncoupled from alleles that are deleterious in hybrids. Our analyses further indicate that selection on swordtail hybrids stems predominantly from deleterious combinations of epistatically interacting alleles.

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DOI: 10.1126/science.aar3684

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