Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study
Massimo SartelliDepartment of Surgery, Macerata Hospital, Macerata, ItalyFausto CatenaLuca AnsaloniDepartment of General Surgery, Ospedali Riuniti, Bergamo, ItalyFederico CoccoliniDepartment of General Surgery, Ospedali Riuniti, Bergamo, ItalyDavide CorbellaDepartment of Anestesiology, Ospedali Riuniti, Bergamo, ItalyErnest E. MooreDepartment of Surgery, Denver Health Medical Center, Denver, USAMark A. MalangoniAmerican Board of Surgery, Philadelphia, USAGeorge C. VelmahosDivision of Trauma, Emergency Surgery and Surgical Critical Care, Harvard Medical School, Massachusetts General Hospital, Massachusetts, USARaúl CoimbraDepartment of Surgery, UC San Diego Health System, San Diego, USAKaoru KoikeDepartment of Primary Care & Emergency Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanAri LeppäniemiDepartment of Abdominal Surgery, University Hospital Meilahti, Helsinki, FinlandWalter BifflDepartment of Surgery, Denver Health Medical Center, Denver, USAZsolt J. BaloghDepartment of Surgery, University of Newcastle, Newcastle, NSW, AustraliaCino BendinelliDepartment of Surgery, University of Newcastle, Newcastle, NSW, AustraliaSanjay GuptaDepartment of Surgery, Govt Medical College and Hospital, Chandigarh, IndiaYoram KlugerDepartment of General Surgery, Rambam Health Care Campus, Haifa, IsraelFerdinando AgrestaSalomone Di SaverioGregorio TugnoliElio JovineCarlos A. OrdóñezDepartment of Surgery, Fundación Valle del Lilí, Cali, ColombiaJames WhelanDivision of Trauma/Critical Care Department of Surgery Virginia Commonwealth University, Richmond, VA, USAGustavo Pereira FragaDivision of Trauma Surgery, Campinas University, Campinas, BrazilCarlos Augusto GomesGerson Alves Pereira JúniorDepartment of Surgery, Emergency Unit, Ribeirão Preto, BrazilKuo‐Ching YuanDepartment of Surgery, Chang Gung Memorial Hospital, Taoyuan, TaiwanMiklosh BalaDepartment of General Surgery, Hadassah Medical Center, Jerusalem, IsraelMiroslav P. PeevDivision of Trauma, Emergency Surgery and Surgical Critical Care, Harvard Medical School, Massachusetts General Hospital, Massachusetts, USAOffir Ben‐IshayDepartment of General Surgery, Rambam Health Care Campus, Haifa, IsraelYunfeng CuiDepartment of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin, ChinaSanjay MarwahDepartment of Surgery, Pt BDS Post-graduate Institute of Medical Sciences, Rohtak, IndiaSanoop Koshy ZachariahDepartment of Surgery, MOSC Medical College, Cochin, IndiaImtiaz WaniDepartment of Surgery, SKIMS, Srinagar, IndiaMuthukumaran RangarajanDepartment of Surgery, Kovai Medical Center, Coimbatore, IndiaBoris SakakushevFirst Clinic of General Surgery, University Hospital/UMBAL/St George Plovdiv, Plovdiv, BulgariaVictor KongDepartment of Surgery, Edendale Surgery, Pietermaritzburg, Republic of South AfricaAdamu AhmedDepartment of Surgery, Ahmadu Bello University Teaching Hospital Zaria, Kaduna, NigeriaAshraf AbbasDepartment of Surgery, Mansoura University Hospital, Mansoura, EgyptRicardo Alessandro Teixeira GonsagaDepartment of Surgery, Faculdades Integradas Padre Albino, Catanduva, BrazilGianluca GuercioniNereo VettorettoElia PoiasinaDepartment of General Surgery, Ospedali Riuniti, Bergamo, ItalyRafael Díaz-NietoDepartment of General and Digestive Surgery, Virgen de la Victoria, University Hospital, Malaga, SpainDamien MassalouDepartment of General Surgery and Surgical Oncology, Université de Nice Sophia-Antipolis, Universitary Hospital of Nice, Nice, FranceM ŠkrovinaDepartment of Surgery, Hospital and Oncological Centre, Novy Jicin, Czech RepublicIhor GerychGoran AugustinDepartment of Surgery, University Hospital Center Zagreb, Zagreb, CroatiaJakub KenigVladimir KhokhaDepartment of Surgery, Mozyr City Hospital, Mozyr, BelarusCristian TranàDepartment of Surgery, Ancona University, Ancona, ItalyKenneth Yuh Yen KokDepartment of Surgery, Ripas Hospital, Bandar Seri Begawan, BruneiAlain Chichom‐MefireClinical Sciences, Regional Hospitals Limbe and Buea, Limbe, CameroonJae Gil LeeSeverance HospitalSuk‐Kyung HongDivision of Trauma and Surgical Critical Care, Department of Surgery, University of Ulsan, Seoul, Republic of KoreaHelmut Alfredo Segovia LohseWagih GhnnamDepartment of Surgery, Mansoura University Hospital, Mansoura, EgyptAlfredo VerniVarut LohsiriwatDepartment of Surgery, Faculty of Medicine Siriraj Hospital, Bangkok, ThailandBoonying SiribumrungwongDepartment of Surgery, Thammasat University Hospital, Pathumthani, ThailandTamer El ZalabanyAlberto TavaresDepartment of Surgery, Hospital Regional de Alta Especialidad del Bajio, Leon, MexicoGian Luca BaiocchiClinical and Experimental Sciences, Brescia Ospedali Civili, Brescia, ItalyKoray DaşJulien JarryVisceral Surgery, Military Hospital Desgenettes, Lyon, FranceM ZidaVisceral Surgery, Teaching Hospital Yalgado Ouedraogo, Ouedraogo, Burkina FasoNorio SatoDepartment of Primary Care & Emergency Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanKiyoshi MurataDepartment of Acute and Critical care medicine, Tokyo Medical and Dental University, Tokyo, JapanTomohisa ShokoThe Shock Trauma and Emergency Medical Center, Matsudo City Hospital, Chiba, JapanTakayuki IraharaEmergency and Critical Care Center of Nippon Medical School, Tama-Nagayama Hospital, Tokyo, JapanAhmed O HamedelneelDepartment of Surgery, Our Lady of Lourdes Hospital, Drogheda, IrelandNoel NaidooA. R. K. AdesunkanmiDepartment of Surgery, Obafemi Awolowo UNiversity Hospital, Ile-Ife, NigeriaYoshiro KobeDepartment of Emergency and Critical Care Medicine, Chiba University Hospital, Chiba, JapanWataru IshiiDepartment of Emergency and Critical Care Medicine, Chiba University Hospital, Chiba, Japan ; Depatment of Emergency Medicine, Kyoto Second Red Cross Hospital, Kyoto, JapanKazuyuki OkaTajima emergency & Critical Care Medical Center, Toyooka Public Hospital, Toyooka, Hyogo, JapanYoshimitsu IzawaEmergency and Critical Care Medicine, Jichi Medical University, Shimotsuke, JapanHytham K. S. HamidDepartment of Surgery, Mayo General Hospital Castlebar Co. Mayo, Castlebar, IrelandIqbal KhanDepartment of Surgery, Mayo General Hospital Castlebar Co. Mayo, Castlebar, IrelandAK AttriDepartment of General Surgery, Rambam Health Care Campus, Haifa, IsraelRajeev SharmaDepartment of General Surgery, Rambam Health Care Campus, Haifa, IsraelJuán SanjuánDepartment of Surgery, Fundación Valle del Lilí, Cali, ColombiaMarisol BadielDepartment of Surgery, Fundación Valle del Lilí, Cali, ColombiaRita Barnabé
2014en
ABI
Annotatsiya
The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).
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