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Carnosine and Related Peptides: Therapeutic Potential in Age-Related Disorders

José H. Cararo1 Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduaçãoem Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, BrazilEmílio L. Streck2 Laboratório de Bioenergética, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, BrazilPatrícia Fernanda Schuck1 Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduaçãoem Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, BrazilGustavo C. Ferreira3 Laboratório de Bioenergética, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

2015en

ABI

Annotatsiya

Imidazole dipeptides (ID), such as carnosine (β-alanyl-L-histidine), are compounds widely distributed in excitable tissues of vertebrates. ID are also endowed of several biochemical properties in biological tissues, including antioxidant, bivalent metal ion chelating, proton buffering, and carbonyl scavenger activities. Furthermore, remarkable biological effects have been assigned to such compounds in age-related human disorders and in patients whose activity of serum carnosinase is deficient or undetectable. Nevertheless, the precise biological role of ID is still to be unraveled. In the present review we shall discuss some evidences from clinical and basic studies for the utilization of ID as a drug therapy for age-related human disorders.

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DOI: 10.14336/ad.2015.0616

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