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Investigation of CO2 Extract of Portulaca oleracea for Antioxidant Activity from Raw Material Cultivated in Kazakhstan

Meruyert I. TleubayevaDepartment of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Department of Engineering Disciplines, School of Pharmacy, NJSC Karaganda Medical University on the Karaganda Medical University, Almaty 050000, Tole Bi 88 Str, KazakhstanР. М. АбдуллабековаDepartament of Pharmaceutical Disciplines and Chemistry, NJSC Karaganda Medical University, Karaganda 100008, Gogol 40 Str, KazakhstanUbaidilla DatkhayevDepartment of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Department of Engineering Disciplines, School of Pharmacy, NJSC Karaganda Medical University on the Karaganda Medical University, Almaty 050000, Tole Bi 88 Str, KazakhstanMargarita IshmuratovaDepartment of Botany, Karaganda Buketov University, Karaganda 100024, Universitetskaya 28 Str, KazakhstanMereke AlimzhanovaDepartment of Thermal Physics and Technical Physics, Faculty of Physics and Technology, Al-Farabi Kazakh National University, Almaty 050040, Al-Farabi Ave 71, KazakhstanKaldanay KozhanovaDepartment of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Department of Engineering Disciplines, School of Pharmacy, NJSC Karaganda Medical University on the Karaganda Medical University, Almaty 050000, Tole Bi 88 Str, KazakhstanAida SeitaliyevaDepartment of Fundamental Medicine Faculty of Medicine and Health, Al-Farabi Kazakh National University, Almaty 050040, Al-Farabi Ave 71, KazakhstanKairat ZhakipbekovDepartment of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Department of Engineering Disciplines, School of Pharmacy, NJSC Karaganda Medical University on the Karaganda Medical University, Almaty 050000, Tole Bi 88 Str, KazakhstanZhanar IskakovaResearch Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Nur-Sultan 010000, Satpaev 2 Str, KazakhstanElmira SerikbayevaDepartment of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Department of Engineering Disciplines, School of Pharmacy, NJSC Karaganda Medical University on the Karaganda Medical University, Almaty 050000, Tole Bi 88 Str, KazakhstanE. V. Flisyuk

2022en

ABI

Annotatsiya

Medicinal plants remain as an important resource in the fight against many diseases, especially in developing countries. Antioxidants are substances capable of delaying, retarding, and preventing the oxidation of lipids or substances that delay or prevent free radical reactions during lipid oxidation. Natural antioxidants such as ascorbic acid, tocopherol, phenolic compounds, and flavonoids are a safe alternative to chemical antioxidants. In present work, results of antioxidant activity of raw materials from the cultivated plant Portulaca oleracea are presented. The extraction time was optimized to 780 minutes; the yield of extractive substances was 1.25% in the production of CO2 extract under subcritical conditions. For the first time, the antioxidant activity of Portulaca oleracea CO2 extract was determined by the amperometric method. Gas chromatography-mass spectrometry (GC-MS) chemical analysis of Portulaca oleracea CO2 extract dissolved in hexane revealed 37 components, including a complex mixture of aldehydes, alkanes, alkenes, esters, diterpenes, steroids, vitamin E, and carbohydrates. The investigation results showed that the Portulaca oleracea CO2 extract was promising for pharmaceutical, cosmetic, and food industries and had great potential for the prevention and treatment of diseases caused by oxidative stress.

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Identifikatorlar

DOI: 10.1155/2022/6478977

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