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Polyethylenimine Is a Strong Inhibitor of Human Papillomavirus and Cytomegalovirus Infection

Gilles A. SpodenDepartment of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, GermanyKatrin BesoldInstitute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, GermanySteffi KrauterInstitute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, GermanyBodo PlachterInstitute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, GermanyNils HanikDepartment of Chemistry, University of Fribourg, Fribourg, SwitzerlandAndreas F. M. KilbingerDepartment of Chemistry, University of Fribourg, Fribourg, SwitzerlandCarsten LambertDepartment of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, GermanyLuise FlorinDepartment of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany

2011en

ABI

Annotatsiya

Polyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells with polyethylenimine blocked primary attachment of both viruses to cells, resulting in a significant reduction of infection. In addition, the dissemination of human cytomegalovirus in culture cells was efficiently reduced by recurrent administration of polyethylenimine. Polyethylenimine concentrations required for inhibition of human papillomavirus and cytomegalovirus did not cause any cytotoxic effects. Polyethylenimines and their derivatives may thus be attractive molecules for the development of antiviral microbicides.

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Identifikatorlar

DOI: 10.1128/aac.05147-11

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