Mitochondrial targets for pharmacological regulation of cell adaptation to hypoxia

The review is devoted to the role of a number of mitochondrial factors in the regulation of cell adaptation to hypoxia and ischemia. The mechanisms of cell adaptation involving factors such as the mitochondrial ATP-dependent potassium channel, mitochondrial megapora, mitochondrial nitric oxide synthase, reactive oxygen species are discussed in the paper. The possibility of pharmacological regulation of cell adaptation with help of target action on mitochondrial components is proposed. This approach is a promising direction for drug discovery for correction of diseases with hypoxia and ischemia in their pathogenesis.

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