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MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer

Liang ChenLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaXing ZhangLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaHuimin WangLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaXiaomin LiuLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaXinju ZhangLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaBo ZhengLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaGuangren QianSchool of Environmental Science and Engineering, Shanghai University, Shanghai, 200444, ChinaZhongliang MaLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China

2017en

ABI

Annotatsiya

Lung cancer is the major form of cancer resulting in cancer-related mortality around the world. MicroRNAs are endogenous small non-coding single-stranded RNAs, which can engage in the regulation of gene expression. In this study, miR-18a-5p significantly upregulated in non-small cell lung cancer (NSCLC) tissues and NSCLC cell lines, suggesting an oncogenic function in lung cancer. Additionally, miR-18a-5p can promote carcinogenesis by directly targeting interferon regulatory factor 2 (IRF2). Further experiments indicated that IRF2 can increase cell apoptosis, inhibit cell proliferation and migration ability. Our study demonstrates that miR-18a-5p promotes autophagy in NSCLC. Collectively, these results indicate that miR-18a-5p can not only promote NSCLC by suppressing IRF2, but also will be a promising target in the near future.

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Identifikatorlar

DOI: 10.1038/cddis.2017.145

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