MODERN DIAGNOSTICS, ETIOPATHOGENETIC ASPECTS, AND STRATEGIC DIRECTIONS OF COMPLEX THERAPY FOR ENDOMETRIOSIS IN WOMEN OF REPRODUCTIVE AGE

This fundamental research paper is dedicated to one of the most pressing and socio-medical challenges in modern gynecology, reproductology, and endocrinology—endometriosis pathology. The article provides a fundamental analysis of the molecular-biological basis, hormonal-metabolic dysfunctions, epigenetic modifications of the disease, and their pathological impact on various systems of the female organism. Within the framework of the study, the latest achievements of the obstetric-gynecological schools of the Republic of Uzbekistan are examined, specifically the principles of organ-preserving minimal invasive (laparoscopic) surgery, long-term anti-proliferative hormonal therapy, immunomodulation, and the integrated model of postoperative psycho-social rehabilitation. The primary objective of the research is to improve the methodology for early (pre-clinical) detection of endometriosis in reproductive-aged women presenting with chronic pelvic pain, various degrees of infertility, and hormonal imbalance. Additionally, the article is enriched with scientifically grounded statistical data regarding differential diagnosis algorithms, modern tumor markers (CA-125, HE4), and the pharmacological efficacy of hormonal modulators. The results demonstrate the superiority of innovative diagnostic-therapeutic approaches in preserving the fertile health of women in the conditions of Uzbekistan.

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