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[Association of kidney dysfunction biomarkers with risk factors for development of chronic heart failure in middle-aged and elderly individuals.]

I T MurkamilovI.K.Akhunbaev Kyrgyz State Medical Academy, 92 str. Akhunbaev, Bishkek 720020, Kyrgyzstan, e-mail: [email protected]K A AitbaevInstitution «Salymbekov University» 144 Bokonbayev str., Bishkek 720040, KyrgyzstanV V FominRussian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya str., Moscow 125993, Russian FederationZ A MurkamilovaFamily Medicine Center № 7, str. T. Moldo 3, Bishkek 720040, KyrgyzstanV P MikhinKursk State Medical University, 3 Karl Marks str., Kursk 305041, Russian FederationZ R RayimzhanovN.N.Burdenko Hospital, 3 Hospital Square, Moscow 105094, Russian FederationS S KhakimovInstitution «Salymbekov University» 144 Bokonbayev str., Bishkek 720040, KyrgyzstanG K DuisheevaI.K.Akhunbaev Kyrgyz State Medical Academy, 92 str. Akhunbaev, Bishkek 720020, Kyrgyzstan, e-mail: [email protected]J I SolizhonovRepublican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, 3d Road 6-th Yangi Shahar, Tashkent 100058, UzbekistanT F YusupovaOsh State University, 331 str. Lenin, Osh 723500, KyrgyzstanF A YusupovOsh State University, 331 str. Lenin, Osh 723500, KyrgyzstanM S AbdykadyrovOsh State University, 331 str. Lenin, Osh 723500, KyrgyzstanO T ZakirovOsh State University, 331 str. Lenin, Osh 723500, KyrgyzstanK A GassanovI.K.Akhunbaev Kyrgyz State Medical Academy, 92 str. Akhunbaev, Bishkek 720020, Kyrgyzstan, e-mail: [email protected]I A AbdibaliyevI.K.Akhunbaev Kyrgyz State Medical Academy, 92 str. Akhunbaev, Bishkek 720020, Kyrgyzstan, e-mail: [email protected]

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Annotatsiya

Chronic heart failure (CHF) is the most common pathological condition in geriatric practice. The increasing prevalence of CHF with age is driven by the rapid global rise in non-communicable diseases (NCDs) such as obesity, arterial hypertension, type 2 diabetes mellitus, coronary artery disease (CAD), chronic obstructive pulmonary disease and chronic kidney disease (CKD); their combination is particularly unfavorable. Objective: To investigate the relationship between biomarkers of renal dysfunction and CHF risk factors in middle-aged and elderly individuals with NCDs. This retrospective study included 357 patients (173 men, 184 women) aged 45-74 years. Anthropometric, clinical, laboratory, and instrumental data were analyzed for all patients. The entire cohort was divided into two groups: group 1 - patients with NCDs and LVH (n=136); group 2 - patients with NCDs without LVH (n=221). Results showed that, compared to patients without LVH, those with LVH had significantly higher age, years, systolic blood pressure, prevalence of CAD, cerebrovascular disease, CKD, fibrinogen, cystatin C, creatinine, and proteinuria. Conversely, they had significantly lower hemoglobin levels, red blood cell count, estimated glomerular filtration rate (eGFR), and left ventricular (LV) E/A ratio. In middle-aged and elderly patients with NCDs, statistically significant positive correlations were found between cystatin C levels and blood triglyceride concentration (r=0,163, p<0,05), as well as between cystatin C levels and LV diastolic filling deceleration time (r=0,150, p<0,05). Additionally, eGFR was correlated with LV E/A ratio (r=0,181, p<0,05), LV early diastolic filling deceleration time (r=-0,211, p<0,05), and right ventricular deceleration time (r=-0,166, p<0,05). The findings may serve as cardiorenal markers in implementing a geriatric approach and in developing algorithms for multidisciplinary care for middle-aged and elderly patients with NCDs.

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DOI: 10.34922/ae.2026.39.1.005

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