Production of <sup>11</sup>C‐labeled quinidine and tamoxifen
Dirk Van HaverLaboratory of Organic Chemistry, Krijgslaan, 281 (S. 4)T. VandewalleInstitute of Nuclear Sciences, Proeftuinstraat, 86Guido SlegersCarlo VandecasteeleInstitute of Nuclear Sciences, Proeftuinstraat, 86
ABI
Abstract
Abstract The production of [ 11 C] quinidine and [ 11 C] tamoxifen for use with positron emission tomography is described. The potassium salt of O‐desmethylquinidine and N‐desmethyltamoxifen free base are treated with [ 11 C]methyl iodide at 130°C for 10 min. After HPLC separation, the [ 11 C‐methyl]‐labeled compounds are produced with a radiochemical yield of 60 and 70 % respectively. Injectable activities from 50 to 70 mCi are obtained 1 h after the irradiation; the specific activity is 40–60 mCi/μ mole. The entire production is controlled by a microprocessor.
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