Inclusion complexes of the natural product gossypol
Abstract
Abstract Gossypol, a biologically active compound with a wide spectrum of action (antiviral, immunosuppressive, antifertile, etc.), is a unique compound in the sense of inclusion complex formation. It gives clathrates with all 110 tested low-molecular organic substances. For 80 clathrates single cyrstals have been obtained and their crystallographic parameters have been determined. By the method of X-ray diffraction the structures of 30 inclusion complexes has been solved. The extreme divergence of gossypol clathrate structures is established: clathrates (H-clathrates) with cavities as isolated cells (cryptates), channels (tubulates), intersecting channels (intercalates), clathrates with mixed host-guest matrix and autoclathrates are observed. The existence of 20 groups of isostructural gossypol clathrates is found.