[A comparative study of the efficacy of pharmacological agents in regulating the level of NADPH in the hepatocytes in an acute lesion].

Abstract

Experiments on mice with acute toxic damage to the liver induced by thioacetamide (200 mg/kg) demonstrated inhibited activity of enzymes glucose-6-phosphate dehydrogenase (G-6-PDH), NADPH-dependent isocitrate dehydrogenase and malate dehydrogenase in the hepatocyte mitochondrial and microsomal-cytosol fractions. Pharmacotherapy with membranostabilizers and cytochrome P-450 inducers activated the enzymes under study, the degree of activation depended on agents used.

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