Article

PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS

Umidakhon MakhmudovaTashkent Medical AcademySh. U. HoshimovRepublican Specialized Center of CardiologyG. J. AbdullayevaRepublican Specialized Center of CardiologyAleksandr B. ShekRepublican Specialized Center of CardiologyR. D. KurbanovRepublican Specialized Center of Cardiology

Eurasian heart journaljournal2015en

ABI

Abstract

This review examines the possibility of personalized pharmacotherapy with statins, based on the genotype of the individual patient. Identification of polymorphism of genes, responsible for the metabolism of the liver CYP3A5, CYP2C9 and transport of statins into the liver SLCO1B1, BCRP allows differentiated approach to their appointment and choice. This will not only increase the effectiveness of statins, but also to avoid serious side effects, primarily statin-induced myopathy and toxic hepatitis.

Topics

Pharmacogenetics and Drug Metabolism Computational Drug Discovery Methods Lipoproteins and Cardiovascular Health

Identifiers

DOI: 10.38109/2225-1685-2015-2-57-61

Citations and references

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