Phytoecdysteroids-containing extract from <i>Stachys hissarica</i> plant and its wound-healing activity
N. Sh. RamazanovInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Tashkent, UzbekistanIsomiddin D. BobayevInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Tashkent, UzbekistanUgiloy Yusufovna YusupovaInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Tashkent, UzbekistanNamuna K. AliyevaDepartment of Natural Sciences, Kokand State Pedagogical Institute, Kokand, UzbekistanФ. Р. ЭгамоваInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Tashkent, UzbekistanNigora Kh. YuldashevaInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Tashkent, UzbekistanВ. Н. СыровInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan
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Abstract
A number of phytoecdysteroid compounds, such as ecdysterone, polipodin V, 2-deoxy-20-hydroxyecdysone, integristeron A and 2-deoxydizon were isolated from Stachys hissarica plant and their structures were confirmed by NMR, mass and IR spectroscopy. In addition, the biological activity of the S. hissarica plant's extract was tested on rats for wound healing activity. It was shown that the extract at repeated oral (per os) administration at a dose of 10 mg/kg speeds up the healing process of linear skin wounds in rats. The wound-healing activity of S. hissarica extract is confirmed to be effective and exceeds known drug methyluracil (2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine), especially in case of alloxan induced diabetic animals.
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