Article

The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones

E. O. Terent’evaInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesС. А. СасмаковInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesSh. A. AzimovInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesВалентина И. ВиноградоваInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesJaloliddin AbdurakhmanovInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesZ. S. KhashimovaInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesA. Sh. SaidovSamarkand State University

Bulletin of Taras Shevchenko National University of Kyiv Series “Psychology”journal2017en

ABI

Abstract

The antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antibacterial properties against all the microorganism strains and strong antifungal activity against Candida albicans with greater inhibition area than the reference drug. IC50 value of the compound is 2,1±0,1 μg/ml, LD50 value is 324,9±18,2 mg/kg.

Topics

Synthesis and Biological Activity Chemical synthesis and alkaloids Chemical synthesis and pharmacological studies

Identifiers

DOI: 10.17721/1728_2748.2017.74.51-55

Citations and references

Cited by 2 11 references

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