Article

Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes

Merve BasCenter for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, TurkeySibel DağlilarDepartment of Metallurgical and Materials Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul 34220, TurkeyNilgün KuşkonmazDepartment of Metallurgical and Materials Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul 34220, TurkeyCevriye KalkandelenCenter for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, TurkeyGökçe ErdemirDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul 34093, TurkeySerap Erdem KurucaDepartment of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa Campus, Istanbul 34093, TurkeyDilshat U. TulyaganovTurin Polytechnic University in Tashkent, 17 Small Ring Street, Tashkent 100095, UzbekistanTomohiko YoshiokaGraduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1, Tsushima, Kita-ku, Okayama 700-8530, JapanOğuzhan GündüzCenter for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, TurkeyDenisa FicaiDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 1-7 Gh Polizu Street, 060042 Bucharest, RomaniaAnton FicaiAcademy of Romanian Scientists, Ilfov st. 3, 060042 Bucharest, Romania

International Journal of Molecular Sciencesjournal2020en

ABI

Abstract

Natural calcium phosphates derived from fish wastes are a promising material for biomedical application. However, their sintered ceramics are not fully characterized in terms of mechanical and biological properties. In this study, natural calcium phosphate was synthesized through a thermal calcination process from salmon fish bone wastes. The salmon-derived calcium phosphates (sCaP) were sintered at different temperatures to obtain natural calcium phosphate bioceramics and then were investigated in terms of their microstructure, mechanical properties and biocompatibility. In particular, this work is concerned with the effects of grain size on the relative density and microhardness of the sCaP bioceramics. Ca/P ratio of the sintered sCaP ranged from 1.73 to 1.52 when the sintering temperature was raised from 1000 to 1300 °C. The crystal phase of all the sCaP bioceramics obtained was biphasic and composed of hydroxyapatite (HA) and tricalcium phosphate (TCP). The density and microhardness of the sCaP bioceramics increased in the temperature interval 1000-1100 °C, while at temperatures higher than 1100 °C, these properties were not significantly altered. The highest compressive strength of 116 MPa was recorded for the samples sintered at 1100 °C. In vitro biocompatibility was also examined in the behavior of osteosarcoma (Saos-2) cells, indicating that the sCaP bioceramics had no cytotoxicity effect. Salmon-derived biphasic calcium phosphates (BCP) have the potential to contribute to the development of bone substituted materials.

Topics

Bone Tissue Engineering Materials Calcium Carbonate Crystallization and Inhibition biodegradable polymer synthesis and properties

Identifiers

DOI: 10.3390/ijms21218082

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