Pharmacological Activity Of The Possessing New Atypical Neuroleptics 1-Phenyltetrahydroisoquinoline Structure
Zafar Isomiddinovich SanoevCandidate Of Medical Sciences, Senior Scientific Researcher Of Department Of Pharmacology And Toxicology Of Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan,Tashkent, UzbekistanYuriy Rahmanovich MirzaevCandidate Of Medical Sciences, Senior Scientific Researcher Of Department Of Pharmacology And Toxicology Of Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan,Tashkent, Uzbekistan
ABI
Abstract
The first synthesized derivative of (3,4-methylenedioxyphenyl) -6,7-methylenedioxy-1,2,3,4tetrahydroquinoline, conventionally designated F-29, showed neuroleptic properties -they have hypothermic, cataleptogenic, less pronounced suppression of motor activity, lack of central adreno-and M-anticholinergic action and less toxic in severity comparable to the activity of a more close analogue of the neuroleptic haloperidol, which has motor and autonomic disorders [1], which F-29 lacks.
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