Pre-Clinical Study Of Safeness Of The Drug Ferulen
Abstract
The acute toxicity, cumulative effect and chronic toxicity of the drug "Ferulen" were studied. During the experiments on white mice and rats with oral injection, it was found that the drug ferulen by the parameters of acute toxicity belongs to the category of practically non-toxic substances (V-class). The coefficient of sexual and species sensitivity of the drug is not expressed. Ferulen is not accumulated in the body of animals when used repeatedly. Long-term use of ferulen for 90 days is well experienced by experimental animals. At the same time, biochemical parameters indicated that there was a deduction in urea, cholesterol, lipoproteins and lipids, as well as decrease in testosterone and luteinizing hormone in the blood serum. In pathomorphological and histological studies a significant decrease in the mass of androgen-dependent organs and destructive changes were found.