SYNTHESIS AND STUDY OF THE REACTION KINETICS OF HOMOVERATRILAMINE WITH BRASSYLIC ACID BY HPLC
I KhSamarkand State University, UzbekistanA. Sh. SaidovSamarkand State University, UzbekistanN.K. MukhamadievSamarkand State University, UzbekistanВалентина И. ВиноградоваSamarkand State University, UzbekistanV VinogradovaInstitute of the Chemistry of Plant Substances as of the Republic of UzbekistanS LiuJ HaungI BarveS HuangSunI IvanovS NikolovaD AladjovI StefanovaP ZagorchevA SaidovSamarkand State University, UzbekistanM LevkovichM AlimovaVinogradovaShK TurgunovAdizov ShR OkmanovYaB TashkhodjaevMazur ShTurgunov YuE TerentyevaZ KhashimovaN TseomashkoYeAzimova ShZhurakulov ShSasmakov ShAbdurakhmanovKhashimovaEva TerentSasmakov AbdurakhmanovD VinogradovaVE TerentevaTsayN MukarramovMuhamadiyevA IshankulovD TukhtaevMukhamadiev
ABI
Abstract
In this work, amide, isoquinoline were synthesized and the kinetics of the reaction of homoveratrylamine with brassilic acid was studied by HPLC. The conditions of (high-performance liquid) chromatographic separation were revealed, which allow satisfactory separation of the components of the reaction mixture consisting of reagents, intermediates and products of the reactions of condensation and cyclization. By studying the kinetic laws, it was found that the reactions of condensation and cyclization obey the first-order kinetic equation and the activation energy is, respectively, 172.3 kJ / mol for the amide condensation reaction, and 118.8 kJ / mol for the cyclization reaction.
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