Description of the Mechanism of Positive Inotropic Action of the Isoquinoline Alkaloid F-18
Shavkat Yu. RustamovInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanInoyat Z. JumayevInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanSadriddin N. BoboevInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanEldor B. IbragimovInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanPulat B. UsmanovInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanSherzod ZhurakulovInstitute of Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent, Uzbekistan
ABI
Abstract
This study evaluated the mechanism of inotropic effect of an isoquinoline alkaloid derivative, 1-(2´-bromine-4´,5´-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4- tetrahydroisoquinoline (F-18) using electrically stimulated rat left ventricular papillary muscle of rat. The F-18 alkaloid have been shown to have positive inotropic effect on papillary muscle contraction activity, IC50 value -14,6 µM. Са2+L-channel blocker - nifedipine was used in experiments. Inotropic effects of F-18 isoquinoline alkaloid on cardiomyocytes were suggested, based on results obtained in experiments carried in cardiomyocytes SR Ca2+- transport systems modulation.
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