Secondary Metabolites and their Biological Activities from Endophytic Fungal Strain<i>Aspergillus terreus</i>XJA8 Associated with<i>Vernonia anthelmintica</i>
Nigora RustamovaDepartment of Biology, Samarkand State University, University Boulevard 15, Samarkand 703004, UzbekistanKhayrulla BobakulovInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 77, 100170 Tashkent, UzbekistanNiu LitaoKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Road 40- Urumqi, Xinjiang 830011, PR ChinaRehebati NuerxiatiKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Road 40- Urumqi, Xinjiang 830011, PR ChinaAhmidin WaliKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Road 40- Urumqi, Xinjiang 830011, PR ChinaWilliam N. SetzerDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USAAbulimiti YiliKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Road 40- Urumqi, Xinjiang 830011, PR China
ABI
Abstract
Two isocoumarins (6-methoxymellein and 6-hydroxymellein), one pyrrole compound (minaline), one lactone derivative (butyrolactone II), five phenolic acids (phenylacetic, veratric (3,4-dimethoxybenzoic), 4-hydroxyphenylacetic, 4-hydroxybenzoic and protocatechuic acid), and two phenolic acid methyl esters ((2-hydroxyphenyl) acetic acid methyl ester and methyl 4-hydroxyphenylacetate), along with 1,3-bis(4-hydroxyphenyl) propan-2-one were isolated from the fungal strain Aspergillus terreus XJA8. The fungal strain was isolated from the root of the medicinal plant Vernonia anthelmintica for first time. All isolated secondary metabolites were evaluated for their antimicrobial activity and melanin synthesis in murine B16 cells.
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