Article

STUDY OF N-DEACETYLAPPACONITINE (N-DAL) ANTICONVULSANT ACTION

Z.I. SanoevInstitute of Plant Chemistry Tashkent, UzbekistanT.T. KhamroevYunusov Institute of Plant Chemistry Tashkent, UzbekistanI.T. AbdinazarovYunusov Institute of Plant Chemistry Tashkent, UzbekistanA. Z. SadikovYunusov Institute of Plant Chemistry Tashkent, UzbekistanS.D. RakhimboevInstitute of Plant Chemistry Tashkent, UzbekistanS.Z. RashidovInstitute of Plant Chemistry Tashkent, Uzbekistan

Oriental Journal of Medicine and Pharmacologyjournal2022en

ABI

Abstract

In this article, we studied an anticonvulsant model induced by different analyzers of corazole (80 mg/kg s.c.), strychnine (1.2 mg/kg s.c.), isoniazid (300 mg/kg ip) and bicuculin (2.7 mg/kg s.c.) when administered orally to white mice, N-deacetylappaconitin at doses of 0.01; 0.05; 0.1; 0.5; 1.0 and 2.0 mg/kg anticonvulsant effect of the test substance, comparative drug carbamazepine and control groups. The anticonvulsant effect of N-deacetylappaconitine, carbamazepine and the control group at various doses was studied and the necessary conclusions were drawn.

Topics

Plant-based Medicinal Research Pharmacological Receptor Mechanisms and Effects Berberine and alkaloids research

Identifiers

DOI: 10.37547/supsci-ojmp-02-02-04

Citations and references

Cited by 2 7 references

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