Bioactivity profiling of <i>Sanghuangporus lonicerinus</i> : antioxidant, hypoglycaemic, and anticancer potential via <i>in-vitro</i> and <i>in-silico</i> approaches
Yusufjon GafforovCentral Asian Center of Development Studies, New Uzbekistan UniversitySofija S. BekićDepartment of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi SadManzura YarashevaJovana MiškovićDepartment of Biology and Ecology, Faculty of Sciences, ProFungi Laboratory, University of Novi SadNemanja ŽivanovićDepartment of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi SadJiajia ChenEdward T. PetriDepartment of Biology and Ecology, Faculty of Sciences, University of Novi SadBekhzod AbdullaevCentral Asian Center of Development Studies, New Uzbekistan UniversitySylvie RapiorCEFE, Univ Montpellier, CNRS, EPHE, IRD, Natural Substances and Chemical Mediation TeamYoung Woon LimSchool of Biological Sciences and Institute of Biodiversity, Seoul National UniversityIkram AbdullaevArshad Mehmood AbbasiDepartment of Environmental Sciences, COMSATS University IslamabadSoumya GhoshNatural and Medical Sciences Research Centre, University of NizwaWan Abd Al Qadr Imad Wan‐MohtarFunctional Omics and Bioprocess Development Laboratory, Institute of Biological Sciences, Faculty of Science, Universiti MalayaMilena RašetaDepartment of Biology and Ecology, Faculty of Sciences, ProFungi Laboratory, University of Novi Sad
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Abstract
O extracts to estrogen receptor α (ERα), ERβ, androgen receptor (AR), and glucocorticoid receptor (GR), with molecular docking providing structural insights. LC-MS/MS analysis revealed solvent-dependent phenolic profiles, with the EtOH extract containing the highest total phenolic content (143.15 ± 6.70 mg GAE/g d.w.) and the best antioxidant capacity. The EtOH extract showed significant hypoglycaemic effects, with 85.29 ± 5.58% inhibition of α-glucosidase and 41.21 ± 0.79% inhibition of α-amylase. Moderate ERβ binding suggests potential for estrogen-mediated cancer therapy, while strong AKR1C3 inhibition by the EtOH extract supports its therapeutic potential.
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