Article

Chemical Profile and Anti-Inflammatory Effects of Taifi Grapes (Vitis L.)

Aziza Qodirali qizi Azimova1Department of Chemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UzbekistanIbrohim Rahmonovich Asqarov2Department.. of Chemistry, Andijan State University, Andijan, UzbekistanAkmal Islomov3Department of Physicochemical Methods of Research, Proteins and Peptides, and Pharmacology, A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, UzbekistanArofat Inkhonova4Department of Pharmacy, Alfraganus University, Tashkent, Uzbekistan Uchqun3Department of Physicochemical Methods of Research, Proteins and Peptides, and Pharmacology, A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, UzbekistanЛ. У. Махмудов3Department of Physicochemical Methods of Research, Proteins and Peptides, and Pharmacology, A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, UzbekistanShukhrat Khakberdiyev5Department . of Chemical Engineering, Jizzakh Polytechnic Institute, Jizzakh, UzbekistanOybek Aripdjanov6Department of Technology of purification of natural gas Tashkent Institute of Chemical Technology (TICT) Tashkent, Uzbekistan,Gulomboy Bekturdiyev6Department of Technology of purification of natural gas Tashkent Institute of Chemical Technology (TICT) Tashkent, Uzbekistan,

Biomedical & Pharmacology Journaljournal2025

ABI

Abstract

This study investigates the chemical composition and pharmacological properties of Vitis L. seed extracts, highlighting their potential as natural therapeutic agents. High-performance liquid chromatography (HPLC) revealed that the extracts contain essential amino acids (proline, phenylalanine, threonine), simple carbohydrates (fructose, glucose), and several water-soluble vitamins (C, B1, B6, B9, B12). Spectroscopic analyses (FTIR and UV-Vis) confirmed the presence of hydroxyl, carbonyl, and aromatic groups characteristic of polyphenols, with UV absorption bands suggesting resveratrol and related flavonoids. In vivo acute toxicity testing demonstrated that the extracts are safe at doses up to 2000 mg/kg, with no mortality or notable physiological disturbances, classifying them as practically non-toxic. Anti-inflammatory activity was evaluated using the carrageenan-induced paw edema model, where the seed extract produced a dose-dependent inhibition of inflammation. The 200 mg/kg dose showed an anti-inflammatory effect comparable to indomethacin. The findings indicate that Vitis L. seed extracts possess a favorable safety profile and notable anti-inflammatory potential. These characteristics support their prospective use in nutraceutical and pharmaceutical formulations aimed at managing oxidative stress and inflammation-related conditions.

Topics

Phytochemicals and Antioxidant Activities Nuts composition and effects Horticultural and Viticultural Research

Identifiers

DOI: 10.13005/bpj/3320

Citations and references

Cited by 1 34 references

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