Correction of mPTP Dysfunction by some Polyphenol extracts
Nuriddin Najmiddinovich SoliyevPhD Student of Namangan State University, UzbekistanGulbakhor T. AbdullayevaProfessor of Tashkent State Technical University Named After Islam Karimov, DSc. UzbekistanMuzaffar I. AsrarovProfessor of the Institute of Biophysics and Biochemistry at the National University of Uzbekistan, DSc. UzbekistanGaybullo X. LutpillaevPhD student Institutе оf Biооrgаniс Сhеmistrу Nаmеd Аftеr А.S. Sаdikоv. Uzbekistan, TashkentSakhiba MadrakhimovaPhD student Institutе оf Biооrgаniс Сhеmistrу Nаmеd Аftеr А.S. Sаdikоv. Uzbekistan, TashkentR. N. RakhimovPhD in Chemical Sciences, Senior Researcher, Institute of Bioorganic Chemistry Named After Acad. A.S. Sadykova ASRUz, UzbekistanSadbarkhon Abdukarimovna MavlanovaHead of the Department of Physiology of Namangan State University, Ph.D UzbekistanZiyofat B. KhosilovaKarshi State University, Department of Physiology. Uzbekistan
ABI
Abstract
Annotation: In this article studied the corrective effect of polyphenol extracts PF-1, isolated from the Karelinia caspia plant and PF-4, isolated from the leaf of quince (Cydonia oblonga), growing in the Republic of Uzbekistan, on the permeability of mPTP in the liver of rats was studied. Studies have shown that polyphenol extracts PF-1 and PF-4(1μg/ml, 5μg/ml, 10μg/ml, 15μg/ml) induce mitochondrial mPTP in the presence of Ca2+ ions. The mPTP inhibitory activities of PF-1 and PF-4 polyphenol extracts ranged from 30% to <83%. The results obtained make it possible to create membrane-active drugs based on extracts of polyphenols PF-1 and PF-4.
Topics
Identifiers
Citations and references
Cited by 048 references
Metrics — AkademScholar · Coming soon