Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3- <i>d</i> ]pyrimidin-4(3 <i>H</i> )-ones and evaluation of their influence on melanin synthesis in murine B16 cells
Li Fei NieKey Laboratory of Plant Resources and Chemistry in Arid Regions , State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , South Beijing Rd 40-1 , Urumqi 830011 , P. R. ChinaGuozheng HuangKey Laboratory of Plant Resources and Chemistry in Arid Regions , State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , South Beijing Rd 40-1 , Urumqi 830011 , P. R. ChinaKhurshed BozorovInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan , MirzoUlugbek Str. 77 , Tashkent 100170 , UzbekistanJiangyu ZhaoKey Laboratory of Plant Resources and Chemistry in Arid Regions , State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , South Beijing Rd 40-1 , Urumqi 830011 , P. R. ChinaChao NiuKey Laboratory of Plant Resources and Chemistry in Arid Regions , State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , South Beijing Rd 40-1 , Urumqi 830011 , P. R. ChinaШ. Ш. СагдуллаевInstitute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan , MirzoUlugbek Str. 77 , Tashkent 100170 , UzbekistanHaji Akber AisaKey Laboratory of Plant Resources and Chemistry in Arid Regions , State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , South Beijing Rd 40-1 , Urumqi 830011 , P. R. China
ABI
Abstract
Abstract A diversity-oriented synthesis of amide-containing thieno[2,3- d ]pyrimidin-4(3 H )-ones is reported. All compounds were tested for their influence on melanin synthesis in murine B16 cells. The azepine fragment in thieno[2,3- d ]pyrimidin-4(3 H )-one skeleton significantly increases the melanin content.
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