Effects of nebivolol on lipid peroxidation and lipid?s spectrum in patients with arterial hypertension
Аннотация
The aim of this study is to evaluate the influence of Nebivolol on lipoperoxidation's (LP) processes and lipid metabolism in patients with arterial hypertension (AH). 32 patients with mild and moderate AH aged 30-65 years old were examined. LP was determinated in erythrocytes, lipid's level was defined in blood from patent's vein before and after therapy of Nebivolol. Nebivolol was administrated in dosage 5 mg once daily as a monotherapy for three mounths. Dynamic control of LP's parameters and lipid metabolism carried out. Therapy of Nebivolol suppressed the LP and activated antioxidant enzymes: level of malon dialdehyde was decreased on 14,6 nmole/min/ml, common antioxidant activity was increased on 5,6%. Nebivolol didn’t influence significantly on levels of lipoproteids with very low density and lipoproteids with high density. We must admit that common holesterole's level reduced on 4,5%, lipoproteid's with low density level reduced on 7,3%. Therefore, results of our investigation demonstrated, that Nebivolol suppressed LP, activated antioxidant system effectively and decreased lipid's level slightly in patients with AH.