Summarization on the Synthesis and Radionuclide-labeling of Peptide Nucleic Acid for An Oligonucleotide Analogue(In Chinese)
Аннотация
Peptide nucleic acid(PNA),which is one kind of antisense nucleic acid compounds and an oligonucleotide analogue that binds strongly to DNA and RNA in a sequence specific manner,has its unique advantages in the field of molecular diagnostics and treatment of diseases.Now,people gradually attach more importance to PNA.To optimize the application of PNA in genetic research and therapy,a great number of backbone modifications on the newly-type structures of PNA were synthesized to improve its physicochemical properties, such as hybridization speciality,solubility in biofluid,or cell permeability. The modified PNA labeled with radionuclides,which can obtain the aim at specific target and minimal non-target trauma,has important role in research and application of tumorous genitherapy.Here a review on the basic synthesis idea and several primary synthetic methods of PNA analogs was given,and also correlative studies and expectation on the compounds belonging to PNA series labeled with radionuclides were included.