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Аннотация
ЛИТЕРАТУРНЫЕ ОБЗОРЫIntroduction: Chronic kidney disease (CKD) is an important health/social problem worldwide [4,5,17,21,47].CKD patients are at higher risk for developing cardiovascular and cerebrovascular diseases, including ischaemic stroke (IS) in comparison with individuals who do not have CKD [3,5,23,27].It is known that presence of kidney disorders in patients with cardiovascular diseases is a predictor for unfavorable disease outcome.Proteinuria and declined glomerular filtration rate (GFR) are considered markers for negative outcome cardiovascular practice [4,5,27].Kidney disorders are also accompanied by high mortality rate and unfavorable clinical outcome in stroke [31,48].Currently, intravenous systemic thrombolysis therapy remains as one of the most effective routine treatment for acute IS [6,42,45,46].However, impact of CKD on outcome of stroke and hemorrhagic complications after thrombolytic therapy has not been established.Research data shows that, increased level of serum creatinine or decreased GFR act as predictors of unfavorable clinical outcome at three months following intravenous thrombolytic therapy in IS cases [29,32], whereas a number of researchers have been unable to identify association between GFR<60 ml/min/m 2 and negative outcome or death [11].On the other hand, pro- ЯДЯБИЙЙАТ ИЪМАЛЫ