Effect of Epigenetic Modifiers on Fermentation Parameters of Endophytic Fungi from Plants Growing in Uzbekistan
Аннотация
The present study aimed to investigate the effects of addition of epigenetic modifiers in the growth medium on biomass and secondary metabolites production in the suspension cultures of the endophytes Thielavia microspora MO46L with antimicrobial activity, isolated from Melissa officinalis, Penicillium concavoradulozum VE89L and Aspergillus amstelodami VR177L isolated from Vinca plants, both producing vinblastine and vincristine. The obtained data showed that quercetin and nicotinamide affected the physiological and cultural properties of studied endophytic strains as well as their metabolic profile. Results of this study also showed that quercetin can be used to induce the synthesis of vinblastine as target product in the endophytic fungi P. concavoradulozum VE89L and A. amstelodami VR177L.