C<sub>28</sub> Terpenoids from Lamiaceous Plant <i>Perovskia scrophulariifolia</i>: Their Structures and Anti-neuroinflammatory Activity
Naonobu TanakaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, JapanKanji NiwaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, JapanSeita KajiharaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, JapanDaisuke TsujiGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, JapanKohji ItohGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, JapanNilufar Z. MamadalievaInstitute of the Chemistry of Plant Substances, Academy Sciences of of the Republic of Uzbekistan, Tashkent 100170, UzbekistanYoshiki KashiwadaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan
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Аннотация
Structurally unique C28 terpenoids, perovsfolins A (1) and B (2), were isolated from the aerial parts of an Uzbek medicinal plant, Perovskia scrophulariifolia (Lamiaceae). Their chemical structures including an unprecedented 6/8/6/6/6 pentacyclic carbon skeleton with a C6–C3 ester moiety were elucidated on the basis of spectroscopic analyses aided by density functional theory calculations as well as chemical evidence. Perovsfolin B (2) exhibited an anti-neuroinflammatory activity.
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