Synthesis of 2-chloro-n-(3-hydroxyphenyl) Acetamide and 2-chloro-n-(4-hydroxyphenyl) Acetamide and Study of Their Antimicrobial Activity
Mukhriddin YusufovNational University of Uzbekistan named after Mirzo Ulugbek, 100174, Tashkent, University str, 4T.S. KholikovNational University of Uzbekistan named after Mirzo Ulugbek, 100174, Tashkent, University str, 4С. А. СасмаковAcad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,Farkhod EshboevAcad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,Jaloliddin AbdurakhmanovAcad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,Shakhnoza S. AzimovaAcad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,
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Аннотация
In this work, the results of chloroacetylation of m- and p-aminophenols in the presence of acetic acid, acetonitrile and tetrahydrofuran as a solvent were presented. Methods of purification of the obtained substances were described. The structure of synthesized substances is established by methods of IR, PMR, mass spectroscopy. The antibacterial and antifungal activities of these compounds were investigated. The results of the screening revealed that the compounds showed the appreciable antibacterial activity against Gram-positive and Gram-negative bacteria, whereas compounds did not exhibit any potential antifungal activity.
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