The forecast of the course of chronic obstructive pulmonary disease with obstructive-apnoea syndrome during sleep
Аннотация
<b>Objective:</b> Assess the four-year survival prognosis of patients with chronic obstructive pulmonary disease (COPD) accompanied by the obstructive sleep apnea/hypopnea syndrome (OSAHS). <b>Methods and Materials:</b> In this study, 62 patients with COPD, who were diagnosed with OSAHS using polysomnography and underwent a comprehensive clinical and functional evaluation. <b>Outcomes:</b> In individuals suffering from COPD and concomitant OSAHS, a more complicated progression of the disease has been observed, characterized by an increase in the severity of dyspnea, a worsening of functional airway obstruction, and a reduction in exercise capacity. The progression of the disease was presented with cardiovascular disorders in 77.4% and obesity in 95.2% of COPD and OSAHS cases. Assessment of the BODE index, a tool used to quantify the severity of COPD, demonstrated that only 35.5% of individuals had a 4-year survival rate of 57%. Analysis of the relationship between the BODE index and parameters such as SaO2 and the maximum desaturation in patients with COPD and OSAHS revealed a strong inverse correlation between the BODE index and the maximum desaturation (r = -0.78) as well as an inverse correlation between the BODE index and the average SaO2 (r = -0.37). Conversely, a direct correlation was observed between the BODE index and the apnea-hypopnea index (r = 0.7). A 12-year follow-up study of COPD patients with OSAHS revealed a mortality rate of 22.2%, primarily among patients with severe OSAHS.