Study of the Activity of Newly Synthesized 1,2,3-Triazole Derivatives in Various Inflammation Models
Аннотация
Inflammation is a universal protective mechanism of the body that occurs in response to pathological changes caused by phlogogenic agents. The progression of the inflammatory process depends on the balance between pro-inflammatory and anti-inflammatory cytokines, primarily on the level of anti-inflammatory cytokine synthesis. The anti-inflammatory effect of triazole derivatives is based on the inhibition of the cyclooxygenase-2 enzyme, which enhances the synthesis of inflammatory mediators such as prostaglandins, bradykinin, and serotonin from arachidonic acid. In the study of the anti-inflammatory effects of 13 newly synthesized derivatives of 1,4-disubstituted 1H-1,2,3-triazole on the models of «formalin-induced paw edema», «carrageenan-induced paw edema» and «serotonin-induced aseptic arthritis» compound 5 at a dose of 100.0 mg/kg demonstrated the highest anti-inflammatory activity - 78%, 77.4%, and 79.8%, respectively. The study of the effect of this compound on the cytokine dynamics in blood serum revealed that, compared to the control group animals, it increased the level of IL-4 by 3.25 times, decreased the level of IL-6 by 5.16 times and reduced the level of TNF-α by 3.48 times.