NATRIY KARBOKSIMETILTSELLYULOZA ASOSIDAGI YANGI POLIMER GIDROGELNING O‘ZLASHTIRILISHINI EKSPERIMENTAL O‘RGANISH
Аннотация
Relevance. Fibrotic changes in filtration blebs after antiglaucoma surgeries limit the success of surgical glaucoma treatment. Therefore, there is a need for the development and evaluation of biocompatible and safe hydrogels. Purpose of the study. To study the local and general tolerability of a new polymer hydrogel when instilled into the eye of a rabbit under experimental conditions. Materials and methods. The study involved 12 (24 eyes) laboratory rabbits. The main group consisted of 4 (8 eyes) rabbits that were instilled with 3,5% Na-CMC hydrogel. The comparison group consisted of 4 (8 eyes) rabbits that were instilled with viscoelastic, and the control group consisted of 4 (8 eyes) rabbits that were instilled with 0.9% sodium chloride solution. The general condition of the animals, toxic-allergic reactions, and ophthalmological parameters (conjunctiva, cornea, intraocular pressure, and pupil diameter) were assessed. Results. The 3,5% Na-CMC hydrogel was well tolerated: the general condition of the animals remained within physiological norms, and no toxic or allergic manifestations were observed. Biomicroscopic examinations revealed no pathological changes in the anterior segment of the eye. Mild, temporary conjunctival hyperemia was observed but did not lead to persistent morphological changes. Intraocular pressure and pupil diameter remained within normal ranges. Conclusion. The 3,5% Na-CMC hydrogel demonstrates high biocompatibility and safety, making it a promising agent in ophthalmology, particularly for the preventionof fibrotic scarring after antiglaucoma surgeries.