Chemical composition and cytotoxicity of the essential oil of <i>Calophyllum fraseri</i> M.R.Hend. & Wyatt-Sm
Nur Nabilah Mohd ZainiDepartment of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan IdrisWan Mohd Nuzul Hakimi Wan SallehDepartment of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan IdrisNurunajah Ab GhaniAtta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARAAbubakar Siddiq SalihuDepartment of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan IdrisMohd Hafiz ArzmiDepartment of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, IIUM Kuantan CampusPanattaporn KumsangBiomedical Science Program, Faculty of Science, Mahidol UniversityBodee NuthoDepartment of Pharmacology, Faculty of Science, Mahidol UniversityFarkhod EshboevInstitute of Advanced Studies, New Uzbekistan UniversitySherali KuzievDepartment of Biochemistry, National University of UzbekistanFeruzbek Khasanov
ABI
Аннотация
values of 93.4 ± 0.15 μg/mL (HepG2), 89.2 ± 0.11 μg/mL (MCF-7), and 96.3 ± 0.12 μg/mL (A549). Molecular docking results revealed favourable interactions between γ-muurolene and Akt1, α-humulene and oestrogen receptor α (ERα), and α-cubebene and the epidermal growth factor receptor tyrosine kinase (EGFR-TK) domain. These docking results provide supportive molecular insights into potential target interactions of individual constituents rather than direct predictors of the biological activity of the crude essential oil.
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