Jerusalem Artichoke Inulin and Glucose Metabolism: Clinical Potential

This article examines the clinical potential of inulin derived from Jerusalem artichoke (Helianthus tuberosus L.) in the management of glucose metabolism disorders. The mechanisms of action of inulin-type fructans are discussed, including modulation of gut microbiota, production of short-chain fatty acids, improvement of insulin sensitivity, and reduction of inflammation and oxidative stress. Evidence from meta-analyses of randomized controlled trials demonstrates significant reductions in fasting blood glucose, HbA1c, insulin levels, and HOMA-IR in patients with prediabetes and type 2 diabetes mellitus. Regular intake of approximately 10 g/day of inulin for at least 6–8 weeks is shown to be an effective adjunct to standard therapy and lifestyle interventions. Dose titration is recommended to improve gastrointestinal tolerability.

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