EVALUATION OF THE EFFECT OF EPITRIAZOLINE ON THE GENERAL BLOOD COUNT, BIOCHEMICAL AND MACROSCOPIC CONDITION OF THE INTERNAL ORGANS OF EXPERIMENTAL ANIMALS WITH PROLONGED ADMINISTRATION
Zafar SanoevInstitute of Chemistry of Plant Substances named after Academician S.Y. Yunusov, Academy of Sciences of the Republic of UzbekistanTolmas KhamroevInstitute of Chemistry of Plant Substances named after Academician S.Y. Yunusov, Academy of Sciences of the Republic of UzbekistanIbrohimjon AbdinazarovInstitute of Chemistry of Plant Substances named after Academician S.Y. Yunusov, Academy of Sciences of the Republic of UzbekistanSuhrob RakhimboevInstitute of Chemistry of Plant Substances named after Academician S.Y. Yunusov, Academy of Sciences of the Republic of UzbekistanSohib RashidovInstitute of Chemistry of Plant Substances named after Academician S.Y. Yunusov, Academy of Sciences of the Republic of UzbekistanDilnoza IsmailovaInstitute of Chemistry of Plant Substances named after Academician S.Y. Yunusov, Academy of Sciences of the Republic of UzbekistanBurhon ElmuradovInstitute of Chemistry of Plant Substances named after Academician S.Y. Yunusov, Academy of Sciences of the Republic of Uzbekistan
Pharmacy and pharmacologyjournal2026
ABI
Аннотация
Experimental studies have revealed that the compound 4-(6-phenyl-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazine-3-yl)-aniline, called epitriazoline, has high anticonvulsant activity when administered orally to experimental animals at doses of 0.25, 2.5 and 25 mg/kg per for 90 days, it does not adversely affect changes in body weight and the macroscopic condition of internal organs. It was revealed, based on a general blood test and biochemical parameters, that epitriazoline is not toxic and does not cause side effects, which indicates the possibility of using it in the future in medical practice in the treatment of epilepsy.
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