Targeted Drug Delivery Systems Using Nanoparticles
Аннотация
Background: The usage of Targeted Drug Delivery Systems (TDDS) reliant on nanoparticles recently obtained marked attention because they show promise for methodical drug delivery along with enhanced security and operational performance. This research investigates the performance, obstacles, and views of healthcare workers, scientists, and university students about utilizing nanoparticles to develop drug delivery platforms. Objectives: The key objective of this research project involves evaluating how nanoparticles deliver therapeutic drugs to patients in cancer treatment and gene therapy applications. The study also considers the difficulties found during nanoparticle drug delivery system development and application by investigating regulatory challenges and concerns about drug toxicity, system stability, and cost. Methods: The research utilizes a quantitative method through structured questionnaires handed out to 250 participants, healthcare professionals, students, and pharmaceutical researchers. Participants responded to questioning through single-choice attributes and multiple-response criteria to share their understanding, perceptions, and knowledge about nanoparticle drug delivery systems. The data analysis included frequency distributions, percentage breakdowns, and mean score calculations using ShapiroWilk testing and Cronbach's Alpha reliability assessment for data measurement consistency. Results: The Shapiro-Wilk test showed the continuous variables about nanoparticle effectiveness and challenges deviated from normal distribution. The scale reliability measurement indicated through Cronbach's Alpha proved inadequate, with a value of -0.176 for Effectiveness and challenges assessment. The boxplot confirmed an inconsistent measurement of constructs, which demands revising the questionnaire delivery method. Conclusions: The study demonstrates potential opportunities and obstacles of nanoparticle drug delivery methods; however exposes critical weaknesses in data reliability and distribution systems. The questionnaire needs further development to improve consistency and accuracy in evaluating participant perception because the scoring deviated significantly from Cronbach's Alpha standard. Research in the field needs to develop a better survey instrument and use non-parametric statistics to analyze nanoparticle delivery systems effectively.