Статья

Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)

Michael PoteserDepartment of Environmental Health, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, AustriaFederica LaguzziUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska-Institutet, Nobels väg 13, Box 210, 17177 Stockholm, SwedenThomas SchettgenInstitute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, GermanyNina VogelGerman Environment Agency (UBA), 14193 Berlin, GermanyTill WeberGerman Environment Agency (UBA), 14193 Berlin, GermanyAline MurawskiGerman Environment Agency (UBA), 14193 Berlin, GermanyPhillipp SchmidtGerman Environment Agency (UBA), 14193 Berlin, GermanyMaria RütherGerman Environment Agency (UBA), 14193 Berlin, GermanyMarike Kolossa‐GehringGerman Environment Agency (UBA), 14193 Berlin, GermanySónia NamoradoDepartment of Epidemiology, National Institute of Health Dr. Ricardo Jorge, 1649-016 Lisbon, PortugalAn Van NieuwenhuyseLaboratoire National de Santé (LNS), L-3555 Dudelange, LuxembourgBrice M. R. AppenzellerDepartment of Precision Health, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, LuxembourgEdda DufþaksdóttirFaculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, 102 Reykjavik, IcelandKristín ÓlafsdóttirDepartment of Pharmacology and Toxicology, University of Iceland, 120 Reykjavik, IcelandLine Småstuen HaugNorwegian Institute of Public Health, Lovisenberggata 8, 0456 Oslo, NorwayCathrine ThomsenNorwegian Institute of Public Health, Lovisenberggata 8, 0456 Oslo, NorwayFabio BarboneDepartment of Medical Area, DAME, University of Udine, 33100 Udine, ItalyValentina RosolenInstitute for Maternal and Child Health-IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyLoïc RambaudSanté Publique France, French Public Health Agency (ANSP), 94415 Saint-Maurice, FranceMargaux RiouSanté Publique France, French Public Health Agency (ANSP), 94415 Saint-Maurice, FranceThomas GöenInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg, Henkestraße 9-11, 91054 Erlangen, GermanyStefanie NüblerInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg, Henkestraße 9-11, 91054 Erlangen, GermanyMoritz SchäferInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg, Henkestraße 9-11, 91054 Erlangen, GermanyKarin Haji-Abbas-ZarrabiInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg, Henkestraße 9-11, 91054 Erlangen, GermanyLiese GillesVITO Health, Flemish Institute for Technological Research (VITO), 2400 Mol, BelgiumLaura Rodríguez MartínVITO Health, Flemish Institute for Technological Research (VITO), 2400 Mol, BelgiumGreet SchoetersVITO Health, Flemish Institute for Technological Research (VITO), 2400 Mol, BelgiumOvnair SepaiUK Health Security Agency, London SE1 8UG, UKEva GovartsVITO Health, Flemish Institute for Technological Research (VITO), 2400 Mol, BelgiumHanns MoshammerDepartment of Environmental Health, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria

Toxicsjournal2022en

ABI

Аннотация

Acrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014-2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000-2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years.

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Темы

Potato Plant Research

Идентификаторы

DOI: 10.3390/toxics10080443

Цитирования и источники

Цитирований: 1 Использованных источников: 60

Показатели — AkademScholar