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The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix

Максим ЙоновA.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, 83, st, Kh. Abdullaev, Tashkent, 100125, Uzbekistan. [email protected]I. I. TukfatullinaA.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, 83, st, Kh. Abdullaev, Tashkent, 100125, UzbekistanB. A. SalakhutdinovA.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, 83, st, Kh. Abdullaev, Tashkent, 100125, UzbekistanN. I. BaramA.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, 83, st, Kh. Abdullaev, Tashkent, 100125, UzbekistanMaria BryszewskaDepartment of General Biophysics, University of Łódź, Banacha 12/16, 90-237, Łódź, PolandTakhir AripovA.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, 83, st, Kh. Abdullaev, Tashkent, 100125, Uzbekistan
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Аннотация

In this paper, we present the results of a study on the membrane-active properties of gossypol, its derivatives and their polyvinylpyrrolidone complexes as assessed by differential scanning calorimetry and by the fluorescent probe method. The latter revealed the change in polarization of the incident radiation caused by the action of the polyphenol on the artificial membrane lipid matrix.

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