Synthesis of Selenium Nanoparticles Stabilized with Sodium Carboxymethylcellulose for Preparation of a Long-Acting Form of Prospidine
Khaydar E. YunusovInstitute of Polymer Chemistry and Physics, Academy of Sciences of the Republic Uzbekistan, 700128, Tashkent, UzbekistanA. A. SarymsakovInstitute of Polymer Chemistry and Physics, Academy of Sciences of the Republic Uzbekistan, 700128, Tashkent, UzbekistanFozil Mamaraim Ugli TurakulovInstitute of Polymer Chemistry and Physics, Academy of Sciences of the Republic Uzbekistan, 700128, Tashkent, UzbekistanС. Ш. РашидоваInstitute of Polymer Chemistry and Physics, Academy of Sciences of the Republic Uzbekistan, 700128, Tashkent, UzbekistanT. L. YurkshtovichResearch Institute of Physicochemical Problems, Belarusian State University, 220030, Minsk, BelarusA. V. KokhanResearch Institute of Physicochemical Problems, Belarusian State University, 220030, Minsk, BelarusN. K. YurkshtovichResearch Institute of Physicochemical Problems, Belarusian State University, 220030, Minsk, BelarusV. А. AlinovskayaResearch Institute of Physicochemical Problems, Belarusian State University, 220030, Minsk, BelarusП. М. БычковскийEducational Scientific Production Republican Unitary Enterprise “Unitechprom BSU”, 220045, Minsk, BelarusН. В. ГолубResearch Institute of Physicochemical Problems, Belarusian State University, 220030, Minsk, BelarusSergey O. SolomevichResearch Institute of Physicochemical Problems, Belarusian State University, 220030, Minsk, Belarus
ABI
Аннотация
Stable selenium nanoparticles were synthesized in a sodium carboxymethylcellulose (Na-CMC) solution with a degree of substitution of 0.85 and an average molar weight of 250 000. The shape and size of selenium nanoparticles were determined by dynamic light scattering and UV spectroscopy. It was found that the nanoparticles coated with Na-CMC are stable upon storage for 28 days. A significant prolongation of the release of the prospidine antitumor agent from stabilized nanoparticles has been shown. Broad spectrum drugs, in particular, anticancer drugs and drugs that compensate for selenium deficiency in the body can be produced based on the selenium nanoparticles coated with Na-CMC.
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Показатели — AkademScholar · Скоро