New Icetexane and 20-Norabietane Diterpenes with Trypanocidal Activity from <i>Dracocephalum komarovi</i>
Nahoko UchiyamaGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan, and Scientific Production Center “Botanika” of Uzbek Academy of Sciences, Tashkent 700143, UzbekistanFumiyuki KiuchiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan, and Scientific Production Center “Botanika” of Uzbek Academy of Sciences, Tashkent 700143, UzbekistanMichiho ItoGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan, and Scientific Production Center “Botanika” of Uzbek Academy of Sciences, Tashkent 700143, UzbekistanGisho HondaGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan, and Scientific Production Center “Botanika” of Uzbek Academy of Sciences, Tashkent 700143, UzbekistanYoshio TakedaGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan, and Scientific Production Center “Botanika” of Uzbek Academy of Sciences, Tashkent 700143, UzbekistanOlimjon K. KhodzhimatovGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan, and Scientific Production Center “Botanika” of Uzbek Academy of Sciences, Tashkent 700143, UzbekistanOzodbek AshurmetovGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan, and Scientific Production Center “Botanika” of Uzbek Academy of Sciences, Tashkent 700143, Uzbekistan
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Аннотация
Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 micro M.
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