The role of certain regulatory cytokines in the immunopathogenesis of extrinsic allergic alveolitis
Аннотация
One of the most important areas of immunology has been the development of the concept of an immunocytokine system. To study the concentration of some cytokines involved in the regulation of the immune response in patients with EAA, in particular the production of IL-8 and IL-12. 60 patients with different stage of the disease were examined. All patients with EAA, depending on the stage, were divided into 3 groups: 1 group - acute, 2 group - subacute, 3 group - chronic stage of the disease. Analysis of the IL-8 content of the EAA patients showed that its level in the total group of patients studied is 38.4 ± 2.5 pg / ml and significantly exceeds the values typical for practically healthy individuals (18.1 ± 1.8 pg / ml, p <0.01). When comparing the studied indicators in groups of patients with different stages of the disease, it was revealed that the highest level of IL-8 is registered among patients with acute EAA. In contrast, the level of IL-8 was relatively low in chronic EAA, with intermediate values in patients with subacute EAA. The highest level of IL-12 was in patients in the chronic stage of EAA (159.9 ± 12.0 pg / ml), significantly differing from the parameters of the healthy group (64.8 ± 8.7 pg / ml, p <0.01) and patients with acute the stage of EAA (111.6 ± 10.2 pg / ml, p <0.01). The results showed that EAA during the acute period is accompanied by the most pronounced changes from the pro-inflammatory cytokine IL-8 and the subacute and chronic allergic inflammation was accompanied by pronounced changes in the production of cytokines regulating the cellular immune response in particular IL-12 in patients with EAA.