Influence Of Galangin On Respiration And Oxidative Phosphorylation Of Rat Liver Mitochondria
Аннотация
The influence of galangin on the respiration and oxidative phosphorylation of rat liver mitochondria is studied in vitro conditions. It was found that galangin increases a glutamate oxidation in V2 and V4 states, but it does not affect on the rate of mitochondrial phosphorylating respiration (V3). The respiratory quotient value by Chance dose-dependently decreases. High concentration of galangin raises the ADP:O quotient. At the same time, in low concentration the galangin does not influence on the succinate oxidations, however, with increasing of its concentration the mitochondrial respiration by succinate increases simultaneously. Thus the ADP/O quotient decreases significantly and the respiratory quotient value by Chance, on the contrary, decreases slightly.