EVALUATION OF THE EFFECT OF DIFFERENT GRANULATION METHODS ON THE PHYSICOMECHANICAL PROPERTIES OF AFEROL GRANULES AND TABLETS
Аннотация
The purpose of this study was to comparatively evaluate the influence of different granulation methods on the physicomechanical properties of Aferol granules and tablets containing a high proportion of ferrous fumarate. The methodology was based on a systematic review and meta-analysis of published scientific data, as well as extrapolation of findings obtained for analogous high-dose pharmaceutical formulations. Three granulation methods were compared: wet granulation in a high-shear mixer, dry granulation by roller compaction, and fluidized bed granulation. The results showed that wet granulation provided the most favorable flowability, mechanical strength, and dosage uniformity, whereas dry granulation was associated with increased granule friability and higher tablet abrasion. Fluidized bed granulation demonstrated balanced properties under conditions of strict process control. It was concluded that wet granulation is the most appropriate method for the industrial production of Aferol tablets.