Synthesis of Substituted Thieno[2,3‐<i>d</i>]pyrimidin‐4‐ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
Khurshed BozorovS.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz, Mirzo Ulugbek Street 77, Tashkent 100170Nilufar Z. MamadalievaS.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz, Mirzo Ulugbek Street 77, Tashkent 100170Burkhon ElmuradovS.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz, Mirzo Ulugbek Street 77, Tashkent 100170Doriana TriggianiDepartment for the Innovation in Biological, Agrofoods and Forests Systems (DIBAF), Tuscia University, Laboratory of Plant Cytology and Biotechnology, Largo dell Università, Blocco D, 01100 ViterboDilfuza EgamberdievaDepartment of Biotechnology and Microbiology, National University of Uzbekistan, Tashkent 100174Antonio TiezziDepartment for the Innovation in Biological, Agrofoods and Forests Systems (DIBAF), Tuscia University, Laboratory of Plant Cytology and Biotechnology, Largo dell Università, Blocco D, 01100 ViterboHaji Akber AisaKey Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011Kh. М. ShakhidoyatovS.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz, Mirzo Ulugbek Street 77, Tashkent 100170
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Аннотация
From 2‐amino‐3‐ethoxycarbonyl‐4,5‐dimethyl‐, ‐polymethylenethiophenes ( 1-4 ) were synthesized 2,3‐disubstituted thieno[2,3‐d]dihydropyrrolo‐, tetrahydropyrido‐, and tetrahydroazepino[1,2‐a]pyrimidin‐4‐ones ( 5-16 ) for pharmacological investigations. The 12 compounds ( 5-16 ) were individually evaluated for their antiproliferative activities on mammalian cancer cell models. All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X). In both cases some compounds enhanced cell proliferation.
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