Effects of hydrolysable tannins on native and artificial biological membranes
Marina P. BorisovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaja, 3, Pushchino, Moscow oblast, 142290, RussiaА. А. КатаевRussian Academy of SciencesS. M. MavlyanovInstitute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, ul. Kh. Abdullaeva, 83, Tashkent, 100125, UzbekistanNodira AbdullajanovaInstitute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, ul. Kh. Abdullaeva, 83, Tashkent, 100125, Uzbekistan
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Effects of hydrolysable tannins on plasma membranes of Chara corallina giant cells and lipid bilayer membrane (BLM) were studied. Tannin inhibited chloride channels of alga cell membranes in a dose-dependent manner. Current jumps emerging in BLM in the presence of tannin suggest formation of ion channels, predominantly anion selective. The presence of cholesterol in BLM increased the open state lifetime of the channels. The findings indicate that hydrolysable tannins possess a membrane activity and are capable to form anion channels in a cell membrane.
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