Effect of the liquid form of traditional Chinesemedicine, Hozen-S, on gastric motility in dog

Juzen-taiho-to, a traditional Chinese herbal medicine, is used for patients withanorexia and fatigue in human medicine. In our previous study, a granulated formof Juzen-taiho-to improved vincristine-induced gastrointestinal adverse effectsthrough increasing gastric motility in dogs. However, the effect of Hozen-S, thesweet liquid form of Juzen-taiho-to, on dog gastric motility has not beeninvestigated. Therefore, we examined whether the administration of Hozen-S todogs affects their gastric motility. To further elucidate the mechanism of theeffect of Hozen-S on gastric contraction, we assessed the plasma ghrelin levelof the dog. Finally, we assessed the Hozen-S palatability compared to granulatedJuzen-taiho-to in dogs and the effect on body weight in dogs. Administration ofHozen-S significantly increased gastric motility, plasma ghrelin concentration,and body weight in the dogs. As a result of the palatability evaluation, thesedogs preferred Hozen-S to the granulated Juzen-taiho-to. In conclusion, Hozen-Sadministration to dogs promoted gastric motility by raising the plasma ghrelinlevel. Considering these functional and palatability data, Hozen-S might replacethe granulated type Juzen-taiho-to and become a prominent traditional Chineseveterinary medicament.

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