Total IgE relationship with genetic markers and smoking factor in patients with COPD
Annotatsiya
Smoking is a major risk factor for COPD, and nicotine promotes the development of allergic reactions. Numerous studies have shown that among smokers and their families we can identify people with a high content of immunoglobulin E. Aim: To determine the level of total immunoglobulin E (Ig E) in conjunction with genetic markers and smoking in patients with chronic obstructive pulmonary disease (COPD). Methods: We investigated 50 COPD patients (age 50.1±2.2 years), and the control group consisted of 20 healthy volunteers. The level of total Ig E were determined in serum by ELISA. ABO blood group system, Rh were adjusted by direct hemagglutination on the tablet. Results: Values of total Ig E COPD among smokers marked slightly higher than in non-smokers. The women showed a trend toward increased levels of Ig E compared with men. Significantly higher levels of Ig E were observed in male smokers with COPD compared with nonsmokers. Increasing of total Ig E was frequently observed in patients with III (B) (23,9%) and II (A) blood groups (26 %), whereas in the presence of IV (AB) group normal blood levels of total Ig E were determined. Patients with blood group II (A) had higher values of Ig E in comparison to other blood groups holders (by 16.8%, p<0.05). Elevated levels of total Ig E in the blood of patients with different phenotypes of COPD and Rh systems was approximately the same, indicating the non-involvement of these genetic systems to the formation of serum immunoglobulin concentrations. Conclusion: The elevated total Ig E is a risk factor associated with COPD and II (A) blood group, suggesting genetically caused increased its synthesis in this category of patients.